Scientists decode the 3-D structure of the calcium channel with unprecedented accuracy. With the help of electron cryo-microscopy and a new technique for detecting electrons, they were able to ...

Our laboratory uses a combination of cryo-electron microscopy, x-ray crystallography, and functional approaches to study the mechanisms of eukaryotic ion channels involved in calcium signaling and ...

Atomic level analysis has revealed how two classes of calcium channel blockers, widely prescribed for heart disease patients, produce separate therapeutic effects by acting at different sites on the ...

Researchers from Japan uncovered the dual role of the fifth transmembrane segment (S5) in the type 1 ryanodine receptor (RyR1) channel, crucial for muscle function. They found that mutations in S5 ...

What Are Calcium Channel Blockers? Calcium makes your heart and blood vessels work harder to pump. Calcium channel blockers work by slowing the movement of calcium into the cells of the heart and ...