Cellular senescence is a state characterized by permanent cell-cycle arrest, increased expression of markers such as p16^INK4a and p21^CIP1/WAF1, elevated DNA damage signals (e.g., γ-H2AX) and a ...

Cellular senescence—an irreversible cell-cycle arrest coupled with the production of pro-inflammatory secretions known as SASP—is now viewed as a central driver of musculoskeletal aging. Accumulation ...

Aging cells secrete substances known to promote the growth of cancer cells. The development of drugs that can selectively kill these cells or inhibit the secretion of substances is ongoing. The latest ...

Testing older potential organ donors for dangerous "zombie" cells could help to increase the number of hearts available for transplant, according to research presented at the British Cardiovascular ...

Scientists have identified prematurely aged astrocytes in the brains of Alzheimer’s patients, particularly those with the APOE4 risk gene. Their findings suggest that cellular senescence in these ...

New research profiles mitochondrial circular RNAs in Peripheral Blood Mononuclear Cells (PBMCs) from young and old human ...

This illustration shows the major cell types affected by cellular senescence in various skeletal diseases. As the body ages, senescent cells accumulate in different tissues—including bone, cartilage, ...

Senescent cells, which are damaged and inflammatory, contribute significantly to aging. Researchers at the Max Planck Institute for Biology of Aging have found that worms can enter a senescent-like ...