Precision and timing of gene expression is essential for normal biological functions and, when disrupted, can lead to many human diseases, including cancers. However, how molecular machines—protein ...

The SWI/SNF Ig-Fold for Transcription Factor Interactions or 'SWIFT' domain on mSWI/SNF chromatin remodeling complexes engage proteins called ...

HP1γ interacts with TRIM66 through the PxVxL motif: Crystal structure analysis and binding affinity studies demonstrate a specific interaction between the chromo shadow domain (CSD) of HP1γ and the ...

A number of large, multisubunit complexes have been identified by their ability to remodel chromatin. In the November 14 Sciencexpress, two reports describe an unexpected link between inositol ...

In eukaryotic cells, nucleosomes—composed of histone octamers—address the topological challenge of DNA packaging by condensing the DNA within the nucleus., crucial for genetic information storage and ...