Using whole genome sequencing, copy number signatures were successful in predicting both the presence of chromothripsis and clinical outcomes in patients with newly diagnosed multiple myeloma (MM).

Survival analysis of 409 consecutive patients with newly diagnosed acute myeloid leukemia treated with intensive induction therapy, with or without the addition of gemtuzomab-ozagomicin (GO). This is ...

"Copy number signatures are an important tool that will help to better define patients with high-risk multiple myeloma…The key advantage of copy number signatures is the ability to use them on ...

Cancer cells appear to hijack a genetic pathway involved in DNA repair to drive malignancy and overcome treatment, a study led by UT Southwestern Medical Center researchers shows. Their findings, ...

For more than a decade, scientists have been aware of chromothripsis — the process in which a single chromosome breaks into pieces and is rearranged in random order, enabling cancer cells to evolve ...

A new target for potential treatments for blast phase myeloproliferative neoplasm (BP-MPN), one of the most aggressive forms of leukemia, has been identified by a research team at the University of ...

Cancer is one of the world's greatest health afflictions because, unlike some diseases, it is a moving target, constantly evolving to evade and resist treatment. In a paper published in the December ...

Many types of cells have to be replenished throughout our lives, and healthy cells can divide into two new cells to replace ones that are damaged or worn out. Cell division has to be carefully ...

Scientists describe how a phenomenon known as 'chromothripsis' breaks up chromosomes, which then reassemble in ways that ultimately promote cancer cell growth. Cancer is one of the world's greatest ...