Many diseases are driven by proteins interacting with each other inside cells. But blocking these interactions with drugs is ...

Drug discovery demands speed and precision, with success often hinging on how quickly teams can move compounds through synthesis, purification, and testing. In this project, flexibility and agility ...

Cyclic peptides represent a versatile class of macrocyclic compounds formed by head-to-tail cyclisation of linear amino acid sequences or by incorporation of non-proteinogenic residues. Advances in ...

Scientists at the Ecole Polytechnique Fédérale de Lausanne (EPFL) have addressed a long-standing challenge in the pharmaceutical industry, with the development of a two-step, one-pot method for ...

Small-molecule drugs have been instrumental in alleviating a gamut of ailments, from heart disease to the humble headache, but some experts now think we’ve exhausted the number of targets those drugs ...

TOKYO--(BUSINESS WIRE)--FUJIFILM Corporation announced today that it has developed an innovative screening methodology for cyclic peptides exhibiting high affinity toward membrane proteins 1. This new ...

Peptides, as essential biomolecules linking amino acids and proteins, play a vital role across numerous disciplines, including life science research, drug discovery, biomaterials engineering, and ...

Researchers from the Institute of Process Engineering (IPE) of the Chinese Academy of Sciences have developed a sustainable, biodegradable, biorecyclable material: high-entropy non-covalent cyclic ...

The farnesoid X receptor (FXR) is a bile acid nuclear receptor that plays a crucial role in regulating bile acid and sterol metabolism. Bile acids are natural ligands of FXR, which bind to the ...