Glycosyltransferases (Gtfs) catalyze the formation of a diverse array of glycoconjugates. Small-molecule inhibitors to manipulate Gtf activity in cells have long been sought as tools for understanding ...
Enzymes that use the cofactor thiamin diphosphate (ThDP, 1), the biologically active form of vitamin B 1, are involved in numerous metabolic pathways in all organisms. Although a theory of the ...