Over the past decade, small molecule kinase inhibitors have emerged as promising therapeutics, particularly in oncology. Through data that has emerged during this period, it has become increasingly ...

This study presents a high-throughput TR-FRET assay targeting the FAK FAT domain's interaction with paxillin, identifying four novel small-molecule inhibitors with potential applications in cancer and ...

No drug developer imagines that every kinase-targeting program can be advanced by any single kinase assay format. Most drug developers recognize that if they are to advance a kinase-targeting program, ...

Scientists at BellBrook Labs developed a TR-FRET based version of the company’s Transcreener AMP2/GMP2 Assay, a high throughput screening assay that can be used for hundreds of enzymes, among them ...