In most neurons in the brain, excitatory and inhibitory postsynaptic potentials (EPSPs and IPSPs) interact with different types of voltage-gated channels in the dendrites, and the product of these ...

Binding of 3',5'-cyclic adenosine monophosphate (cAMP) to hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels regulates their gating. cAMP binds to a conserved intracellular cyclic ...

In a surprising new finding, neuroscientists have shown that human neurons have a much lower density of ion channels than expected, compared to the neurons of other mammals. Ion channels produce ...

Electrical signals regulate the rhythmic contractions of the heart muscle and thus control heartbeat. If the signals go awry, the consequences can be lethal. Researchers have now delineated how ...

The process of expressing a wide variety of voltage-gated and ligand-gated ion channels enables nociceptors to transduce receptor potential into single action potentials or multiple action potentials.