Making proteins for research or therapies often starts with cell-line development. In many applications, genetic engineering is used to optimize a cell line for producing high levels of the intended ...
Large molecule biotherapeutics are primarily expressed and produced in mammalian host cells then purified from complex mixtures containing growth media and host cell material. Identifying, monitoring, ...
Viruses have evolved various strategies to coexist and replicate within host cells. Mimicry of host proteins represents a key mechanism that ensures the prolonged persistence of herpesviruses in host ...
Since the first patient received allogeneic hematopoietic cell transplantation (allo-HCT) to treat thalassemia, an inherited blood disorder affecting hemoglobin, in 1982, the therapy has rapidly grown ...
Boosting the cell's own cleanup: New class of small molecules accelerate natural protein degradation
Cells have a remarkable housekeeping system: Proteins that are no longer needed, defective, or potentially harmful are labeled with a molecular "tag" and dismantled in the cellular recycling machinery ...
Tissue processing advance can label proteins at the level of individual cells across whole, intact rodent brains and other large samples just as fast and uniformly as in dissociated single cells. A ...
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