In the intricate regulation of inflammation, metabolic reprogramming and posttranslational modification (PTM) have emerged as pivotal players, offering new avenues for understanding the fine-tuned ...

This multidisciplinary project integrates computational biology, structural modelling, population genomics, and AI. It will provide new mechanistic insights into how coding variation and PTMs ...

Lactylation, a recently identified post-translational modification, has emerged as important for immune regulation, tissue repair, cancer cell metabolism, and now, potentially, Alzheimer’s disease. In ...

A molecular model showing three of the main epigenetic modifications of DNA (orange) and histones (dark blue) [JUAN GAERTNER/Science Photo Library/Getty Images] Post-translational modifications (PTMs) ...

Itaconate and its derivatives regulate immune signaling in activated macrophages by modulating both pro-inflammatory and anti-inflammatory pathways. 4-Octyl itaconate stabilizes NFE2L2 by alkylating ...

Post-traumatic osteoarthritis develops rapidly after joint injury, yet current treatments largely address symptoms rather than restoring damaged cartilage.

Respiratory infections, pink eye, or an upset stomach may seem like unrelated, mild inconveniences, but all of these ailments share one root cause: adenovirus infection. Many of us will encounter some ...

Metabolic syndrome (MetS) is a multifaceted disorder characterized by a constellation of metabolic abnormalities, including central obesity, dyslipidemia, ...