Geneticists looking inside the nuclear genome for mutations that contribute to disease have long relied on a principal known as constraint modeling, which allows researchers to assess the degree of ...

A groundbreaking investigation from the Technical University of Munich has uncovered a crucial link between mitochondrial dysfunction and Crohn’s disease. This revelation could transform the ...

Gene editing technology allows to introduce and correct disease-linked mitochondrial DNA mutations in liver and skin cells In a step toward treating mitochondrial diseases, researchers in the ...

Researchers identified a new, sticky form of mitochondrial DNA damage that builds up at dramatically higher levels than in nuclear DNA. These lesions disrupt energy production and activate ...

As of 2019, about 4.9 million people globally were living with an inflammatory bowel disease (IBD) such as Crohn’s disease. Scientists are still unclear as to the exact cause of Crohn’s disease, which ...

Researchers have developed experimental drugs that encourage the mitochondria in our cells to work a little harder and burn ...

Mitochondria, the tiny organelles without which our bodies would be deprived of energy, are gradually revealing their mysteries. In a new study published in Nature Neuroscience, researchers from ...

For decades, the dream of fixing harmful mutations in mitochondrial DNA felt out of reach. Scientists have long known these mutations cause serious diseases that pass down only through mothers. They ...

Chronic stress and social isolation are frequently cited as precursors to physical illness, yet the biological machinery ...