Welcome back to our NFL Pick'em Pool Picks for Week 18 of the 2025 NFL season. The final week of one of the most chaotic regular seasons in recent memory is here. With much of the playoff field already locked up,

16 - Houston vs. Indianapolis: Houston has clinched a playoff spot and owns the league's top total defense, allowing the fewest yards per game while consistently forcing turnovers in divisional matchups. Indianapolis has struggled with late-season quarterback instability and ranks low in offensive efficiency against elite defenses. Winner-Houston

Three road teams are favored this year. The Rams are double-digit favorites at Carolina – the game that will open the NFL playoffs on Saturday. Buffalo is favored at Jacksonville on Sunday, and the Texans are favored at Pittsburgh on Monday. Which home team – if any – will pull the so-called upset there?

Paul Pabst, WGN Radio Sports Correspondent and one of the Executive Producers for theDan Patrick Show joins John Landecker to talk about the anticipated Soldier Field game where the Bears will

The Bills had the best rushing attack in the NFL this year with an average of 159.6 yards per game. Only one other team in the NFL even topped145 yards per game during the regular season. The Bills went 9-0 in games where they rushed for at least 150 yards thanks in large part to their not-so-secret weapon, James Cook.

The final week of the NFL regular season is here, and there are three massive matchups on the slate. The Carolina Panthers and Tampa Bay Buccaneers will meet with the NFC South on the line, the Pittsburgh Steelers and Baltimore Ravens will battle for the AFC North,