By understanding how milligram to kilogram peptide production is achieved safely, drug developers can better navigate the ...

Nature makes amide bonds—the key linkages that string together amino acids in a polypeptide—like a knitting whiz. The ribosome in Escherichia coli bacteria, for example, can make eight amide bonds in ...

Chemical synthesis and peptide ligation techniques have revolutionised the field of protein engineering by enabling the precise construction of peptides and proteins with tailored modifications. These ...

Scientists at the Ecole Polytechnique Fédérale de Lausanne (EPFL) have addressed a long-standing challenge in the pharmaceutical industry, with the development of a two-step, one-pot method for ...

The breakthrough could simplify the production of complex proteins used in cancer immunotherapy and other advanced medicines ...

(Nanowerk News) Peptides are short strands of amino acids that are increasingly used therapeutically, as biomaterials and as chemical and biological probes. The capacity to isolate, manipulate and ...

Discover how therapeutic peptides act as biological messengers to treat disease, improve metabolism, and enhance immune ...

For decades, a substantial number of proteins, vital for treating various diseases, have remained elusive to oral drug therapy. Traditional small molecules often struggle to bind to proteins with flat ...

Scientists have developed stable orally available cyclic peptides with a much higher bioavailability than current ones, virtually creating a generation of drugs that can target previously untreatable ...