Degenerative disc disease (DDD) and intervertebral disc degeneration (IVDD) represent conditions that impair the function of the spinal motion segments, profoundly affecting quality of life worldwide.

A new research paper was published in Volume 17, Issue 9 of Aging-US on September 8, 2025, titled, "Runx1 overexpression induces early onset of intervertebral disc degeneration." In this study, led by ...

The intervertebral discs between the spinal vertebrae comprise a gel-like core, the nucleus pulposus (NP), encased by a tough, fibrous outer ring. The NP’s high water content allows it to act like a ...

A bulging disc in your lower back is most often caused by naturally occurring changes as you age. Most bulging discs don’t cause symptoms, but they may progress to become herniated discs. Lower back ...