Different genomic alterations in DNA damage repair (DDR) pathways occur in 20% to 25% of advanced prostate cancer, including homologous recombination repair (HRR) gene alterations. Identifying the ...

Therapeutic landscape of Rad51 in cancer treatment. Key elements include (1) DNA damage sources (PARPi, chemo/radiotherapy);(2) repair pathways (Rad51‐mediated HR); (3) intervention strategies (Rad51 ...

Every time a cell divides, its DNA is duplicated so that the two daughter cells have the same genetic material as their parent. This means that millions of times a day a biochemical wonder takes place ...

Phase IIa study of BVAC-C in HPV type 16 or 18 positive recurrent cervical carcinoma. Progression-free survival (PFS) and second PFS (PFS2) by disease stage in patients (pts) with homologous ...

A new research paper was published in Oncotarget's Volume 15 on October 1, 2024, entitled, "Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition." As highlighted in the ...

Scientists have revealed an important mechanism in the repair of DNA double-strand breaks, according to new research. Scientists have revealed an important mechanism in the repair of DNA double-strand ...

The discovery of synthetic lethality between BRCA mutations and PARP inhibitors ranks has led to major advances in the treatment of BRCA-mutated cancers. Mutations in BRCA1 and BRCA2 can leave cells ...

Researchers created a mutated version of RAD51, a DNA repair protein, to better understand its critical functions at key steps in the cell replication process during times of stress. This work may ...

Epithelial ovarian cancer (EOC) is the most common lethal gynecological cancer. Ovarian cancer is usually treated with platinum-based chemotherapy; however, a significant number of patients are ...