Scientists have created a model to study the role of RNA splicing defects in Alzheimer's disease, revealing degeneration and toxicity caused by neuron hyperexcitability. Researchers have puzzled over ...
Q: Does alternative splicing play a role in other diseases? Alternative splicing has been linked to about 15% of human genetic diseases and cancers. Mutations in the components that regulate ...
Pre-mRNA splicing in a subset of human short introns is governed by a distinct mechanism involving a new splicing factor Protein-coding genes carry the blueprint for protein production. In higher ...
Alternative splicing, a clever way a cell generates many different variations of messenger RNAs - single-stranded RNAs involved in protein synthesis - and proteins from the same stretch of DNA, plays ...
Individuals with mutations in the ATM gene develop ataxia-telangiectasia, a neurodegenrative disorder characterized by immunological defects and cancer predisposition. In an Advanced Online ...
Preclinical in vivo data demonstrate hyper-precise mechanism directly targets the disease-causing mRNA repeats leading to correction of splicing defects and reversal of myotonia Company plans to file ...
UNC School of Medicine scientists led a collaboration of researchers to demonstrate a potentially powerful new strategy for treating cystic fibrosis (CF) and potentially a wide range of other diseases ...
Hu, R-C, Zhang, Y., Nitschke, L., Johnson, S.J., Xia, Z. and Cooper, T.A. (2025) MBNL overexpression rescues cardiac phenotypes in a myotonic dystrophy type 1 heart ...
RIVERSIDE, Calif. -- Alternative splicing, a clever way a cell generates many different variations of messenger RNAs — single-stranded RNAs involved in protein synthesis — and proteins from the same ...
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