Asal Shirazi, Founder of ASA Foundation, shares insights into what drives inflammatory responses, including the role of ...

The immune system has evolved to mount immune responses against foreign pathogens and to remain silent against self-antigens. A balance between immunity and tolerance is required as any disturbance ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 15 (April 12, 2022), pp. 1-8 (8 pages) Immunological tolerance is established and maintained by a diverse ...

Scientists from the Institute of Molecular Genetics of the Czech Academy of Sciences, in collaboration with the Faculty of ...

Understanding what autoimmune diseases are, what triggers them and how they’re treated can be a powerful first step toward ...

The 2025 Nobel Prize in Physiology or Medicine was awarded earlier this month to immunologists Mary E. Brunkow (Institute for Systems Biology, Seattle), Fred Ramsdell (Sonoma Biotherapeutics, San ...

A single signaling pathway controls whether immune cells attack or befriend cells they encounter while patrolling our bodies, researchers at Stanford Medicine have found. Manipulating this pathway ...

In the absence of CXCL4 (top row), DNA fragments (green) are delivered to TLR9 (red) in the late endosomes of B cells, with the colocalization of DNA fragments and TLR9 shown in orange, activating a ...

Immune dysregulation is often defined as an immune response that is directed against one of the body’s own tissues, cells or molecules (e.g. autoimmunity) or against an innocuous foreign molecule that ...

Regulatory T cells protect the body from misdirected or overly excited immune responses. A new study highlights previously unknown characteristics of these cells that could guide the development of ...