--CAR constructs representative of anito-cel (D-Domain), cilta-cel (dual VHH), and ide-cel (scFv) were assessed preclinically for tonic signaling and off-target Claudin binding -- -- No tonic ...

A new study reveals that astrocytes—star-shaped support cells traditionally viewed as passive partners of neurons—play a previously underappreciated role in the maturation of coordinated movement. A ...

-- No tonic signaling or off-target activity was observed with the D-Domain, supporting its unique target-specific binding profile and anito-cel’s potentially best-in-class safety profile -- -- ...