How Does Tremfya Work for Crohn's Disease? Tremfya is a type of medicine called a monoclonal antibody. It works by targeting a protein in your body called interleukin-23 (IL-23). IL-23 is a cytokine ...

What Is Tremfya, and Why Does It Matter? Tremfya (guselkumab) is a lab-made, dual-acting antibody medication that reduces inflammation by targeting the interleukin-23 (IL-23) protein and blocking a ...

Tremfya’s more common side effects include upper respiratory infection, headache, injection site reactions, and joint pain. Tremfya may reduce immune system activity and increase the risk of infection ...

Tremfya is used to treat irritable bowel disease (ulcerative colitis and Crohn’s disease) in adults. It’s also approved for plaque psoriasis and psoriatic arthritis in adults and some children.

Tremfya interacts with other biologic immunomodulator drugs, such as abatacept (Orencia) and canakinumab (Ilaris). Tremfya can also interact with tricyclic antidepressants (TCAs), such as ...