In a study published in Nature on January 28, a research team led by Eric H. Xu (Xu Huaqiang) from the Shanghai Institute of ...

Immunotherapy is a modern approach to cancer treatment that uses a patient's own immune system to help fight tumors. It has made an incredible impact on treating cancers in many different organ ...

Bile acids, synthesised from cholesterol in the liver, are central to lipid digestion but also serve as signalling molecules that regulate metabolism, inflammation and cellular homeostasis. In ...

Bile acids, traditionally recognised for their role in lipid digestion, have emerged as key modulators of metabolic homeostasis. Recent research has explored how these endogenous molecules can ...

(A) The classic bile acid synthesis pathway: cholesterol 7α-hydroxylase (CYP7A1) converts cholesterol to 7α-hydroxycholesterol (7α-HOC). The sterol 12α-hydroxylase (CYP8B1) converts the intermediate ...

The concept of "good fats" and "bad fats" has influenced diet trends, public health policy, and biomedical research for ...

There are trillions of microbes in the gastrointestinal tract, and we are starting to learn more about the exact mechanisms that link those microbes and the substances they generate to changes in ...

Bacteria naturally present in the human intestine, known as the gut microbiota, can transform cholesterol-derived bile acids into powerful metabolites that strengthen anti-cancer immunity by blocking ...

A study published in the journal Cell Metabolism finds that hyodeoxycholic acid alleviates non-alcoholic fatty liver disease by modulating the gut-liver axis. Study: Hyodeoxycholic acid alleviates non ...

We need to consume fat to survive, but a new study has shown that the human body can process different types of fats in ...