Ternary complex (TC) and eIF4F complex assembly are the two major rate-limiting steps in translation initiation regulated by eIF2α phosphorylation and the mTOR/4E-BP pathway, respectively. How TC and ...

Recruitment of ribosomes to mRNA templates is generally the rate-limiting step of translation initiation and is mediated by eukaryotic initiation factor (eIF) 4F—a heterotrimeric complex consisting of ...

Since 2006, Ruben Gonzalez’s Columbia lab has used single-molecule light microscopy to study the structural dynamics of biomolecules. In lay person’s terms, that means: They use hyper-powerful ...

Cancer is the Houdini of diseases because it escapes elaborately contrived predicaments. Like Houdini, who was known to emerge triumphant after being handcuffed, locked in a trunk, and tossed into a ...

Scientists have uncovered how one type of T cell creates two genetically identical, but functionally different, daughter cells. Scientists at St. Jude Children's Research Hospital have solved an ...