SK2-containing channels are expressed in the postsynaptic density (PSD) of dendritic spines on mouse hippocampal area CA1 pyramidal neurons and influence synaptic responses, plasticity and learning.
Long-term potentiation (LTP) of synaptic strength at Schaffer collateral synapses has largely been attributed to changes in the number and biophysical properties of AMPA receptors (AMPARs).
They then used molecular dynamics simulations to explore the molecular mechanisms of SK2 channel modulation by PIP2. "Structural insights from our study will be useful to design novel inhibitors of ...
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