HIV integrase is a 32kDa viral protein consisting of three domains- N-terminus, catalytic core domain, and C-terminus, which each have distinct properties and functions contributing to the …

Integration of a desossiribonucleic acid (DNA) copy of the viral ribonucleic acid (RNA) into host genomes is a fundamental step in the replication cycle of all retroviruses. The highly …

Jul 23, 2025 · Integrase is an enzyme whose fundamental role involves the precise cutting and pasting of genetic material, DNA, from one location to another. This ability to manipulate …

Integrase is the enzyme that splices the viral DNA into a cellular chromosome. Four identical copies of integrase grab the two ends of the viral DNA, creating a stable complex called an …

Jul 9, 2021 · Integrase is the viral enzyme responsible for the catalytic steps involved in this process, and integrase strand transfer inhibitors are widely used to treat people living with HIV.

HIV uses integrase to insert (integrate) its viral DNA into the DNA of the host CD4 cell. Integration is a crucial step in the HIV life cycle and is blocked by a class of antiretroviral (ARV) HIV drugs …

Integrase is defined as an essential enzyme encoded by the HIV Pol gene that facilitates the integration of viral DNA genomes into human chromosomes through a series of DNA cutting …

Jul 29, 2023 · Integration of a desossiribonucleic acid (DNA) copy of the viral ribonucleic acid (RNA) into host genomes is a fundamental step in the replication cycle of all retroviruses.

Jan 1, 2009 · Retroviral DNA integration is a multistep process that occurs in defined stages. The viral-encoded integrase (IN) is both necessary and sufficient to catalyze integration (Katz et al. …

Integrase is a viral enzyme responsible for mediating the integration of proviral DNA into the host's genomic DNA, as well as the insertion and excision of gene cassettes at the attC site.