In physical organic chemistry, a kinetic isotope effect (KIE) is the change in the reaction rate of a chemical reaction when one of the atoms in the reactants is replaced by one of its isotopes. [3]

May 5, 2024 · Kinetic Isotope Effects (KIEs) are used to determine reaction mechanisms by determining rate limiting steps and transition states and are commonly measured using NMR to …

What Are Kinetic Isotope Effects? A kinetic isotope effect is a mechanistic phenomenon wherein isotopically substituted molecules react at different rates. Isotopic substitution does not affect the …

In each example, we highlight the cause of the kinetic isotope effect, be it due to tunneling or zero-point energy effects, and compare the accuracy of the different methods in the high and low …

The kinetic isotope effect is defined as the ratio of the rate constants of reactions involving unlabelled and labelled species, primarily reflecting the influence of isotopic substitution on …

Traditional kinetics studies do not provide information as to what bonds are broken/formed and changes in hybridization that occur during the rate-limiting step of a reaction. Isotope effects can provide this …

Aug 2, 2025 · The kinetic isotope effect (KIE) describes how replacing an atom with one of its isotopes—atoms of the same element with different masses due to varying neutron counts—can …

May 28, 2024 · Kinetic isotope effects (KIEs) are a fundamental concept in chemical kinetics and biophysics, providing insights into reaction mechanisms at a molecular level. KIEs occur when a …

May 1, 2017 · The kinetic isotope effect (KIE) is defined as the ratio of the observed rate constants for the natural and heavy isotopically labeled substrate, for example, using protonated (k H) …

Jun 9, 2025 · Explore the fundamentals of Kinetic Isotope Effects and their significance in organic chemistry, including their impact on reaction rates and mechanisms.